Distinguish between a hereditary germline cancer, such as those caused by BRCA1 mutations, and cancers that result from two somatic mutations in the same gene in the same cell.

20. Look up US Patent 5654155 at www.uspto.gov, which covers use of the BRCA1 genes DNA sequence. Discuss what the patent covers and whether you think companies should be permitted to patent gene sequence.
21. Do web research to name a gene, other than BRCA1, that increases risk of developing breast cancer when mutant. What is the process or mechanism that the mutation disrupts?
22. Discuss how alternate splicing can complicate the study of mutations in the BRCA1 gene.
23. Distinguish between a hereditary germline cancer, such as those caused by BRCA1 mutations, and cancers that result from two somatic mutations in the same gene in the same cell.
24. Explain how mutations in the same gene can cause different types of cancers.

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